Metahalones, a new class of metaphase inhibitors

A new class of monoamine oxidase inhibitors.

Newly synthesized compounds have been found to inhibit mitochondrial monoamine oxidase (MAO) in mouse brain and rat liver. A series of 2-acylamino-3-trrt-aminopropiophenones acted preferentially against M A 0 type B (2-phenylethylamine a s substrate) , apparent ly irreversibly. 2Decanoylamino-3-morpholinopropiophenone acted similarly irr live toward the cerebral MAO, producing a dose-related in...

Triarylmethanes, a New Class of Cx50 Inhibitors

The paucity of specific pharmacological agents has been a major impediment for delineating the roles of gap junction (GJ) channels formed by connexin proteins in physiology and pathophysiology. Here, we used the selective optimization of side activities (SOSA) approach, which has led to the design of high affinity inhibitors of other ion channels, to identify a specific inhibitor for channels f...

A New Class of Banach Sequence Spaces

Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.

5-Lipoxygenase is a key enzyme in the metabolism of arachidonic acid to leukotrienes. The preventive efficacy of 5-lipoxygenase inhibitors against lung tumorigenesis was determined in A/J mice given the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in drinking water from week 0 to week +7. Groups of 25 mice were fed either: acetylsalicylic acid (ASA), a cycloo...

Inhibitors of Carbohydrate Processing: A New Class of Anticancer Agents1’2

There is a need for anticancer agents with novel mechanisms of action. Recently identified molecular targets for new anticancer agents include inducers of cell differentiation, cell cycle arrest, and apoptosis, as well as signaling pathways for growth factors and cytokines. Another unexplored opportunity is presented by the ubiquitous intracellular glycoprotein glycosylation pathway. This compl...